Enhanced Oral Bioavailability of Morin Administered in Mixed Micelle Formulation with PluronicF127 and Tween80 in Rats

Enhanced oral bioavailability of morin administered in mixed micelle formulation with PluronicF127 and Tween80 in rats.

To overcome the low oral bioavailability of morin, a mixed micelle formulation with pharmaceutical excipients that facilitate solubilization and modulate P-glycoprotein (P-gp) was developed and evaluated in vitro and in vivo rats. Morin-loaded mixed micelle formulation with a morin-PluronicF127-Tween80 ratio of 1 : 10 : 0.02 (w/w/w) was prepared by a thin-film hydration method. The solubility, ...

A Mixed Micelle Formulation Strategy for Enhancing Oral Bioavailability of Berberine by Modulating P-glycoprotein

Bioavailability Study of Indomethacin Self-nanemulsifying Oral Formulation in Rats

In the present s tudy, a new self-nanoemuls ified drug delivery formulation (SNEDDF) of indomethacin (IND) was tes ted in rats for its in viv o p e rformance. Pharmacokinetic s tudies of IND SNEDDF was carried out after oral adminis tration of the prepared formulation (capsules) and compared with that of orally adminis tered IND oily solution (filled in capsule). From the pharmacokinetic p a ra...

Formulation and evaluation of Itraconazole nanoemulsion for enhanced oral bioavailability.

Itraconazole (ITR), an antifungal agent has poor bioavailability due to low aqueous solubility. The present investigation aimed at development of ITR nanoemulsion to enhance its oral bioavailability. ITR nanoemulsion was prepared using Capmul MCM C8 as oil, Pluronic F68 as co-surfactant and Cremophore EL as surfactant using high speed stirring, followed by probe sonication. Nanoemulsion with av...

Zanamivir Oral Delivery: Enhanced Plasma and Lung Bioavailability in Rats

The objective of this study was to enhance the oral bioavailability (BA) of zanamivir (ZMR) by increasing its intestinal permeability using permeation enhancers (PE). Four different classes of PEs (Labrasol(®), sodium cholate, sodium caprate, hydroxypropyl β-cyclodextrin) were investigated for their ability to enhance the permeation of ZMR across Caco-2 cell monolayers. The flux and Papp of ZMR...